Biometrical Letters Vol. 56(1), 2019, pp. 71-87
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ON THE DISTRIBUTION OF URINE OUTPUT IN NORMALLY CYCLING WOMEN Delwyn G. Cooke1, Leonard F. Blackwell2, Simon Brown3,4 1Science Haven Limited, Palmerston North, New Zealand, e-mail: D.G.Cooke@massey.ac.nz, 2Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand, e-mail: L.F.Blackwell@massey.ac.nz, 3Deviot Institute, Deviot, Tasmania 7275, Australia, e-mail: Simon.Brown@deviotinstitute.org, 4College of Public Health, Medical and Veterinary Sciences, James Cook University, Queensland 4811, Australia |
It has been suggested that it is possible to monitor the menstrual cycle by measuring the concentration of urinary reproductive steroids. This neglects the variation in void volume and in urine production rate. In neither case has any systematic analysis been reported previously. Overnight urine samples were collected each day for one complete cycle by 24 women and the void volumes and intervoid times were recorded. The void volume and urine production rate were approximately lognormally distributed and the intervoid time was approximately normally distributed. Using these distributions we consider the implications of the variation in void volume and urine production rate for the comparison of the concentrations of a urinary analyte in two samples.
distribution, menstrual cycle, urine, urine production rate
